Cole, S A, B D Mitchell, W C Hsueh, P Pineda, B A Beamer, A R Shuldiner, A G Comuzzie, J Blangero, and J E Hixson. 2000. “The Pro12Ala Variant of Peroxisome Proliferator-Activated Receptor-Gamma2 (PPAR-Gamma2) Is Associated With Measures of Obesity in Mexican Americans.”. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity 24 (4): 522-4.
Abstract
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-gamma2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P= 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans.