Overview
We aim to take our findings from the nonhuman primate model of Mtb/SIV co-infection to a humanized mouse model to further define the mechanistic role of the previously identified target markers of interest. We aim to utilize the bone marrow, liver, thymus (BLT) humanized mouse (HuMouse) model that recapitulates the key features of human TB and HIV, including innate, adaptive immune responses and pathological changes,