About
About Our Lab
Our lab uses cross-disciplinary research tools of immunology, microbiology, and chemical biology to profile, identify, and characterize bacterial and mammalian metabolites and lipids, which function as antigens for unconventional T cells or as regulators of other biological processes. We target these metabolites and T cell subsets, particularly the mucosal-associated invariant T (MAIT) cells, to determine their efficacy against Mycobacterium tuberculosis infections and some cancer types in animal and human tissue models.
About Dr. Huang
With an interest in anti-microbial T cell immunity, Shouxiong Huang, Ph.D., characterizes the structures and presentation of small metabolite and lipid antigens to activate unconventional T cells and fight infections such as tuberculosis. Dr. Huang’s studies focus on mucosal-associated invariant T cells and lipid-reactive T cells for their protective responses independent of variable genetics of human individuals. He integrates multidisciplinary expertise, including immunology, microbiology, translational studies and mass spectrometry-based metabolomics and lipidomics, to understand and develop metabolite and cell targets for disease intervention.