CoDe: a web-based tool for codon deoptimization.

Sharma, Divya, Tracey Baas, Aitor Nogales, Luis Martinez-Sobrido, and Michael Gromiha. 2023. “CoDe: a Web-Based Tool for Codon Deoptimization.”. Bioinformatics Advances 3 (1): vbac102.

Abstract

SUMMARY: We have developed a web-based tool, CoDe (Codon Deoptimization) that deoptimizes genetic sequences based on different codon usage bias, ultimately reducing expression of the corresponding protein. The tool could also deoptimize the sequence for a specific region and/or selected amino acid(s). Moreover, CoDe can highlight sites targeted by restriction enzymes in the wild-type and codon-deoptimized sequences. Importantly, our web-based tool has a user-friendly interface with flexible options to download results.

AVAILABILITY AND IMPLEMENTATION: The web-based tool CoDe is freely available at https://web.iitm.ac.in/bioinfo2/codeop/landing_page.html.

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online.

Last updated on 12/15/2023
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