About Our Lab

Lab Highlights

• Discovery of the major phagocytic pathways and microbial ligands for M. tuberculosis in human monocytes and macrophages including bacterial surface mannosylated determinants, complement and complement receptors
• Discovery of the unique biology of alveolar macrophages and the influence of the alveolar environment in shaping these cells including surfactant
• Discovery of the major role that macrophage nuclear receptors play in regulating inflammation and metabolism in human macrophages
• Discovery of the impact of aging in changing the biology of alveolar macrophages
• Identification of key pathways associated with human to human diverse macrophage responses to M. tuberculosis
• Development of human in vitro models for human alveolar macrophages and granuloma structures