CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions.

Amici, Stephanie A, Nicholas A Young, Janiret Narvaez-Miranda, Kyle A Jablonski, Jesús Arcos, Lucia Rosas, Tracey L Papenfuss, Jordi B Torrelles, Wael N Jarjour, and Mireia Guerau-de-Arellano. 2018. “CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions”. Frontiers in Immunology 9: 1593.


Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there are few markers that allow for robust dissection of macrophage phenotype. We recently identified CD38 as a marker of inflammatory macrophages in murine in vitro and in vivo models. However, it is unknown whether CD38 plays a similar marker and/or functional role in human macrophages and inflammatory diseases. Here, we establish that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ) inflammatory stimuli, but not with the alternative stimulus, IL-4. Pharmacologic and/or genetic CD38 loss-of-function significantly reduced the secretion of inflammatory cytokines IL-6 and IL-12p40 and glycolytic activity in human primary macrophages. Finally, monocyte analyses in systemic lupus erythematosus patients revealed that, while all monocytes express CD38, high CD38 expression in the non-classical monocyte subpopulation is associated with disease. These data are consistent with an inflammatory marker role for CD38 in human macrophages and monocytes.

Last updated on 04/15/2022