Our Laboratory focuses on Tuberculosis pathogenesis, as well as other respiratory infectious diseases, and how host comorbidities such aging, diabetes and chronic HIV infection drives host susceptibility to Mycobacterium tuberculosis and other respiratory infections. We take a global approach to our research, studying the host, the pathogen and the complex interactions between them, providing us with a complete picture of infectious processes. Our research is also iterative and comprehensive, building upon basic previous knowledge to define critical interactions that allow us to interrogate in depth how the host environment shapes microbes and their interactions with host cells. We also have a large network of collaborators all over the world, with whom we aim to develop and validate new technologies, therapeutics, vaccines and diagnostic tools.