Imwong, Mallika, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, et al. 2008. “Gene Amplification of the Multidrug Resistance 1 Gene of Plasmodium Vivax Isolates from Thailand, Laos, and Myanmar.”. Antimicrobial Agents and Chemotherapy 52 (7): 2657-9.
Abstract
Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.